In Vitro Susceptibility of 57 Isolates of Plasmodium Falciparum to Atovaquone And Lumefantrine in Abidjan

Authors

  • Trebissou Jonhson Noel David Laboratory of Microbiology National of Public Health (INSP) of Cote d’Ivoire Pharmacodynamics Biochemical Laboratory UFR Biosciences, Felix HouphouetBoigny University
  • Beourou Sylvain Malariology Unit, Pasteur Institute of Cote d’Ivoire
  • Bla Brice k Laboratory of Microbiology National of Public Health (INSP) of Cote d’Ivoire Pharmacodynamics Biochemical Laboratory UFR Biosciences, Felix HouphouetBoigny University
  • Yavo William Laboratory of Microbiology National of Public Health (INSP) of Cote d’Ivoire UFR of Pharmaceuticaland Biological Sciences
  • Djaman Allico Joseph Laboratory of Basic and Clinical Biochemistry, Pasteur Institute of Cote d’Ivoire Pharmacodynamics Biochemical Laboratory UFR Biosciences, Felix Houphouet Boigny University

Abstract

To evaluate the in vitro chemosensitivityof Plasmodium falciparum isolates to lumefantrine (LUM) and atovaquone (ATO). The measurement of the in vitro activity of the two antimalaria molecules was conducted according to the microtest optical variant of the WHO. Out of 64 Plasmodium falciparum isolates tested, 57 (89%) gave interpretable results of in vitro culture. It was found that 67% of them were susceptible to LUM against 33% who were resisting. All were sensitive to ATO. The presence of Plasmodium falciparum isolates resistant to LUM could compromise the effectiveness of artemether-lumefantrine recommended in the treatment of uncomplicated malaria in Côte d'Ivoire. While the combination atovaquone / proguanil is a suitable regimen for malaria prophylaxis.

Keywords:

Plasmodium falciparum, Sensibility in vitro, Lumefantrine, Atovaquone, Côte d'Ivoire

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Published

2013-09-16

How to Cite

David, T. J. N. ., Sylvain, B. ., Brice k, B. ., William, Y. ., & Joseph, D. A. . (2013). In Vitro Susceptibility of 57 Isolates of Plasmodium Falciparum to Atovaquone And Lumefantrine in Abidjan. The International Journal of Biotechnology, 2(9), 154–162. Retrieved from https://archive.conscientiabeam.com/index.php/57/article/view/1507

Issue

Vol. 2 No. 9 (2013)

Section

Articles