Synthesis and Antibacterial Activity of Some Novel N,N-Di-Oxalamide Derivatives

Authors

  • Maha Habash Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Applied Science University, Amman, Jordan
  • Mohammad Yasin Mohammad Department of Pharmaceutical Sciences, Faculty of Pharmacy, Middle East University, Amman, Jordan
  • Manal Ayyash Department of Pharmaceutical Sciences, Faculty of Pharmacy, Applied Science University, Amman, Jordan
  • Mutasem O Taha Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan

DOI:

https://doi.org/10.18488/journal.64/2015.3.12/64.12.165.175

Abstract

Novel N,N-di-oxalamide derivatives 1-6 were synthesized and characterized by the spectroscopic techniques. These derivatives showed good antibacterial activities against Gram-negative organism Escherichia coli and Gram-positive organisms Staphylococcus aureus and Bacillus subtilus. However, compounds 3 and 4 showed potent antibacterial activity against Gram-negative organism Escherichia coliand Gram-positive organism Staphylococcus aureus. In addition to that, we compared their antibacterial profiles with previously synthesized N,N-di-oxalamide derivatives 7-9. The new compounds showed superior antibacterial activities compared to moderate activities for 7-9.

Keywords:

N,N-Di-oxalamide derivatives. Escherichia coli, Staphylococcus aureus, Bacillus subtilus, Antibacterial activity, Sulfonamide derivatives

Abstract Video

Published

2015-12-15

How to Cite

Habash, M. ., Mohammad, M. Y. ., Ayyash, M. ., & Taha, M. O. (2015). Synthesis and Antibacterial Activity of Some Novel N,N-Di-Oxalamide Derivatives. International Journal of Chemistry and Materials Research, 3(12), 165–175. https://doi.org/10.18488/journal.64/2015.3.12/64.12.165.175

Issue

Vol. 3 No. 12 (2015)

Section

Articles