Synthesis, Physico-Chemical and Antimicrobial Properties of Some Metal (II) -Mixed Ligand Complexes of Tridentate Schiff Base Derives From Β-Lactam Antibiotic {(Cephalexin Mono Hydrate)-4-Chlorobenzophenone} and Saccharin

Authors

  • Taghreed H Al-Noor Department of Chemistry.Ibn -Al-Haithem College of Education for pure science Baghdad University, Iraq
  • Amer J Jarad Department of Chemistry.Ibn -Al-Haithem College of Education for pure science Baghdad University, Iraq
  • Abaas Obaid Hussein Department of Chemistry.Ibn -Al-Haithem College of Education for pure science Baghdad University, Iraq

DOI:

https://doi.org/10.18488/journal.65/2014.1.6/65.6.109.120

Abstract

A new Schiff base (4-chlorophenyl)(phenyl methanimine (6R,7R)-3-methyl-8-oxo-7-(2-phenylpropanamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate=HL=C29H24ClN3O4S) has been synthesized from β-lactam antibiotic (cephalexin mono hydrate (CephH)=(C16H19N3O5S.H2O) and 4- chlorobenzophenone. Metal mixed ligand complexes of the Schiff base were prepared from chloride salt of Fe(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), in 50% (v/v) ethanol – water medium in aqueous ethanol(1:1) and Saccharin(C7H5NO3S) containing sodium hydroxide. Several physical tools in particular; IR, C:H:N , 1H NMR,13C NMR for ligand, melting point, molar conductance, magnetic moment. and determination of the percentage of the metal in the complexes by flame(AAS). The ligand and their metal complexes were screened for their antimicrobial activity against four bacteria (gram +ve) and (gram -ve) [Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus]. The proposed structure of the complexes using the program, Chem office 3D (2006) and the general formula have been given for the prepared mixed ligand complexes [M(Sac)3(L)].

Keywords:

Cephalexin antibiotics, Saccharin, Schiff base, Spectral studies, Antibacterial activities

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Published

2014-06-16

How to Cite

Al-Noor, T. H., Jarad, A. J., & Hussein, A. O. . (2014). Synthesis, Physico-Chemical and Antimicrobial Properties of Some Metal (II) -Mixed Ligand Complexes of Tridentate Schiff Base Derives From Β-Lactam Antibiotic {(Cephalexin Mono Hydrate)-4-Chlorobenzophenone} and Saccharin. International Journal of Chemical and Process Engineering Research, 1(6), 109–120. https://doi.org/10.18488/journal.65/2014.1.6/65.6.109.120

Issue

Vol. 1 No. 6 (2014)

Section

Articles