Lactic Acid as Spacer between Poly Acrylic Acid and 4-Aminoantipyrine

Authors

  • Fiyral Mohammad Ali AL-Mustansiriya University, College of Science, Department of Chemistry, Baghdad, Iraq
  • Taghreed Hashim AL-Noor Ibn -Al-Haithem College of Education for pure science, Baghdad University, Iraq
  • Saif Mohsin Ali AL-Mustansiriya University, College of Science, Department of Chemistry, Baghdad, Iraq

DOI:

https://doi.org/10.18488/journal.57/2015.4.6/57.6.36.45

Abstract

Due to many problems associated with drug release and side effects, we could design a novel drug delivery system through modification of poly acrylic acid (AA) with Lactic acid as a spacer between the polymer and 4-aminoantipyrine. In vitro drug release had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37℃. The prepared prodrug polymer was characterized by FTIR and 1H−NMR spectra. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.

Keywords:

Poly acrylic acid, Lactic acid, Prodrug polymer

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Published

2015-06-15

How to Cite

Ali, F. M. ., AL-Noor, T. H., & Ali, S. M. . (2015). Lactic Acid as Spacer between Poly Acrylic Acid and 4-Aminoantipyrine. The International Journal of Biotechnology, 4(6), 36–45. https://doi.org/10.18488/journal.57/2015.4.6/57.6.36.45

Issue

Vol. 4 No. 6 (2015)

Section

Articles