Synthesis, Anti-Inflammatory, Analgesic, Molecular Modeling and Admet Studies of Novel Diclofenac Derivatives Containing Leucinyl Moiety

Authors

  • A.A Elhenawy Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo-Egypt
  • M. A El-Gazzar Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo-Egypt
  • H. M Mohmoud Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo-Egypt
  • W. I El-Eraky Pharmacology department, National Research Center, Cairo, Egypt
  • S.A. W El-Awdan

Abstract

The present work aims to synthesize novel diclofenac derivatives containing L-leucine moiety. The synthesized compounds docked into the active site to discover validated inhibitors of cyclooxygenases (COX-1 and COX-2). The calculations in-silico were predicted that, the compound with lowest energy of docked poses was interacted with residues of active site, perhaps could be making them possible selective inhibitors against (COX-2) and physiologically active. The binding score of compound compared with reference drug, and show extensive interactions with the targets, which may consider it a suitable selective inhibitor against (COX-2).

Keywords:

Leucine, Diclofenac, Cox, Docking, Admet

Published

2013-11-15

How to Cite

Elhenawy, A., El-Gazzar, M. A., Mohmoud, H. M., El-Eraky, W. I., & El-Awdan, S. W. (2013). Synthesis, Anti-Inflammatory, Analgesic, Molecular Modeling and Admet Studies of Novel Diclofenac Derivatives Containing Leucinyl Moiety. International Journal of Chemistry and Materials Research, 1(1), 1–13. Retrieved from https://archive.conscientiabeam.com/index.php/64/article/view/1823

Issue

Vol. 1 No. 1 (2013)

Section

Articles